This book addresses the need of practitioners and researchers in the biomedical sciences to better understand the principles of biomechanics of soft tissue. This book will thoroughly incorporate a number of applications and examples of biomechanics both from an engineering and clinical standpoint. It starts with the fundamental of soft tissues biology and structures. This is followed by providing the basic biomechanical principles such as stress-strain relationship of tissues defining mechanical parameters. In turn, this paves the way for the incorporation of appropriate applications such as radiotherapy, surgery and diagnostics.