مدیریت عفونت مفصل پری پروستیک؛ دیدگاه جهانی در مورد تشخیص، گزینه‌های درمانی، راهبردهای پیشگیری و تأثیرات سودبخش آن‌ها

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دسته: برچسب:
عفونت مفصل پری‌پروستیک (PJI) یکی از جدی‌ترین عوارض در زمینه اندوپروستیک می‌باشد. بنابراین بیمار باید به سرعت درمان مناسب برای مقابله با عفونت را آغاز کند.
متخصصان سراسر جهان، براساس تجربه شخصی خود، روش‌های پیشگیری، استراتژی‌های تشخیصی مناسب جهت بررسی، درمان‌های مؤثر تجدیدپذیر مربوط به جراحی و همچنین تأثیرات سودبخش PJI را مطرح کرده و شرح می‌دهند.
خوانندگان می‌توانند از این کتاب به عنوان منبع جامعی برای مقایسه رویکردهای خودشان جهت درمان PJI با توصیه‌های متخصصان استفاده کنند.
سال انتشار: 2017  |  تعداد صفحات: 366  |  حجم فایل: 10.21 مگابایت  |  زبان: انگلیسی
Management of Periprosthetic Joint Infection: A global perspective on diagnosis, treatment options, prevention strategies and their economic impact
نویسنده:
Klaus-Dieter Kuhn
ناشر:
Springer
ISBN10:
3662544687
ISBN13:
9783662544686

 

عناوین مرتبط:


Periprosthetic joint infection (PJI) is among the most serious complications in the field of endoprosthetics. The number of PJIs is increasing worldwide and poses a real interdisciplinary challenge for everyone involved. For the patient concerned, it is necessary to promptly work out an adequate therapy solution to fight off the infection. Both the clinical experience of the surgeon and the proper diagnostic processes are prerequisite for the reliable detection and identification of an infection. The microbiologist is responsible for identifying the causative germs by screening the patient’s synovial fluid and tissue samples. Based on the findings and subsequent resistance testing, the infectious disease specialist can recommend the appropriate antibiotic therapy. Furthermore, the clinical pharmacist is consulted regularly throughout the therapy to discuss the risk of potential drug interactions. The surgeon will proceed with the revision surgery, following defined algorithms. Adequate radical debridement of infected and necrotic surrounding tissue is the most important step towards a successful cure of the infection. Accompanying the surgery, anti-infective agents are given systemically and locally. While systemic application of anti-infectives mainly reduces the number of haematogenic-spreading planktonic germs, local application immediately forms a colonization barrier and protects the implant from sessile biofilm formation. Concurrently, antibiotics are actively released from the implant, resulting in local germ reduction. Thus, local agents are embedded in the concept of surgical PJI treatment as a reliable adjuvant measure and they sustainably support the successful outcome. In one-stage procedures, local agents are released from specialized antibiotic-loaded bone cements, while in two- or multi-stage procedures, local agents are released from corresponding temporary spacers (interim prostheses). Even from an economic standpoint, the combination of systemic and local agent application is meaningful. Furthermore, there are some interesting trends towards the coating of metallic implants to protect against biofilm formation on the implant surface. On the basis of their personal experience, specialists from all over the world present, explain and discuss preventive approaches, appropriate diagnostic strategies for detection, reproducible effective surgical treatments  as well as the economic impact of PJI. The reader can use this book as a solid platform for comparing their own approach to PJI treatment with the specialists’ recommendations.